JWH‑210 is a synthetic cannabinoid belonging to the naphthoylindole family of compounds. It was originally synthesized during research into cannabinoid receptor activity by chemist John W. Huffman, whose initials form the “JWH” name used for this series of molecules. The compound has the molecular formula C₂₆H₂₇NO and interacts strongly with the CB₁ and CB₂ cannabinoid receptors, which are part of the body’s endocannabinoid system.

JWH‑210 is known for having very strong binding affinity to cannabinoid receptors, making it one of the more potent compounds within its chemical series. Because of its potency and potential health risks, the substance has been placed under strict legal control in many countries, including classification as a Schedule I or similarly controlled substance in several jurisdictions.